Introduction
Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50 = 6nM). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-ß (GSK-3ß) and CDK5/p35 in Alzheimer’s disease. Inhibitor of DNA damage checkpoint at G2 phase(IC50 = 6 µM),cyclin-dependent kinasesCDK1/cyclin B (IC50 = 22 nM),CDK2/cyclin A (IC50= 70 nM), CDK2/cyclin E(IC50= 40 nM), CDK4/cyclin D1 (IC50 = 600 nM), CDK5/p25 (IC50 = 28 nM),GSK-3ß (IC50 = 10 nM),andcasein kinase 1(CK1) (IC50 = 35 nM).
