+44 (0)1223 298875

Anti-Annexin A1 Antibody

Rabbit polyclonal antibody to Annexin A1 from ABclonal (A0767).
Name: Anti-Annexin A1 Antibody
Description: Rabbit polyclonal antibody to Annexin A1.
Applications: WB, IHC, FC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:100, FC: 1:20 - 1:50.
Reactivity: Human
Immunogen: A synthetic peptide of human ANXA1.
Protein Length: 346
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
Tissue Specificity: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
Sequence Similarities: Belongs to the annexin family.
Post-Translational Modification: Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
Cellular Location: Nucleus. Cytoplasm. Cell projection > Cilium. Cell membrane. Membrane. Endosome membrane. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted > Extracellular space. Cell membrane. Secreted > Exosome. Cytoplasmic vesicle > Secretory vesicle lumen. Cell projection > Phagocytic cup. Early endosome. Cytoplasmic vesicle membrane.

Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678).
UniProt: P04083
Gene ID: 301
Synonyms: Annexin 1 Antibody
Annexin I Antibody
Annexin I (lipocortin I) Antibody
Annexin-1 Antibody
AnnexinA1 Antibody
AnnexinI Antibody
ANX 1 Antibody
ANX A1 Antibody
ANX1 Antibody
ANXA 1 Antibody
ANXA1 Antibody
ANXA1 protein Antibody
ANXA1_HUMAN Antibody
Calpactin 2 Antibody
Calpactin II Antibody
Calpactin-2 Antibody
CalpactinII Antibody
Chromobindin 9 Antibody
Chromobindin-9 Antibody
Chromobindin9 Antibody
HGNC:533 Antibody
Lipocortin 1 Antibody
Lipocortin I Antibody
Lipocortin1 Antibody
LipocortinI Antibody
LPC 1 Antibody
LPC1 Antibody
p35 Antibody
Phospholipase A2 inhibitory protein Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of A2058 cells, using ANXA1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
start icons start icons start icons start icons start icons (1)
Description: Goat polyclonal antibody to ANXA1.
Application: ELISA, WB
Host: Goat
Isotype: IgG
Reactivity: Human, Mouse, Rat, Porcine

£205

Description: Rabbit polyclonal antibody to ANXA1
Application: WB, IHC, IF
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human ANXA1.

£234

Description: Rabbit polyclonal antibody to ANXA1.
Application: WB, IHC, IF
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Total Citations (2)
Description: Rabbit polyclonal antibody to Annexin I (N146)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 111-160 of Human Annexin I.

£165 – £283

Please Note: Anti-Annexin A1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0767
Size Price Quantity
100µl £243
200µl £372

or
Request a quotation
Contact Us Directly
  • call icon + 44 (0)1223 298 875
  • + 44 (0)1223 281 447
  • email icon info@antibodies.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe