|Description:||Rabbit polyclonal antibody to Ataxin-1.|
|Dilutions:||WB: 1:200 - 1:500, IF: 1:20 - 1:50.|
|Immunogen:||A synthetic peptide of human ATXN1.|
|Formulation:||Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism.|
|Tissue Specificity:||Widely expressed throughout the body.|
|Involvement in Disease:||Spinocerebellar ataxia 1: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.|
|Sequence Similarities:||Belongs to the ATXN1 family.|
|Post-Translational Modification:||Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity.|
|Cellular Location:||Cytoplasm. Nucleus.
Colocalizes with USP7 in the nucleus.
|Synonyms:||alternative ataxin1 Antibody
Ataxin 1 Antibody
Spinocerebellar ataxia type 1 protein Antibody
|Information:||Target information shown above is from the UniProt Consortium.|