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Anti-Ataxin-1 Antibody

Rabbit polyclonal antibody to Ataxin-1 from ABclonal (A0506).
Name: Anti-Ataxin-1 Antibody
Description: Rabbit polyclonal antibody to Ataxin-1.
Applications: WB, IF
Dilutions: WB: 1:200 - 1:500, IF: 1:20 - 1:50.
Reactivity: Human
Immunogen: A synthetic peptide of human ATXN1.
Protein Length: 815
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism.
Tissue Specificity: Widely expressed throughout the body.
Involvement in Disease: Spinocerebellar ataxia 1: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
Sequence Similarities: Belongs to the ATXN1 family.
Post-Translational Modification: Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity.
Cellular Location: Cytoplasm. Nucleus.

Colocalizes with USP7 in the nucleus.
UniProt: P54253
Gene ID: 6310
Synonyms: alternative ataxin1 Antibody
Ataxin 1 Antibody
ATX1 Antibody
ATX1_HUMAN Antibody
Atxn1 Antibody
D6S504E Antibody
OTTHUMP00000016065 Antibody
SCA1 Antibody
Spinocerebellar ataxia type 1 protein Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of CEM cell lysate using ATXN1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to Ataxin-1
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human Ataxin-1.

£220 – £366

Description: Rabbit polyclonal antibody to Ataxin-1
Application: WB, IHC, IF, ELISA
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776.

£180 – £234

Please Note: Anti-Ataxin-1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0506
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe