+44 (0)1223 298875

Anti-β-Actin (I102) Antibody

Total Citations (110)
Rabbit polyclonal antibody to β-Actin (I102) from Bioworld Technology (AP0060).
Name: Anti-β-Actin (I102) Antibody
Description: Rabbit polyclonal antibody to β-Actin (I102)
Specificity: β-actin (I102) pAb detects endogenous levels of β-actin protein.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human β-Actin.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 42 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Introduction: All eukaryotic cells express actin, which often constitutes asmuch as 50% of total cellular protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of actin are present in mammalian tissues and fall into three classes. -actin expression is limited to various types of muscle, whereas – and -actin are the principle constituents of filaments in other tissues.Members of the small GTPase family regulate the organization of the actin cytoskeleton. Rho controls the assembly of ctin stress fibers and focal adhesion, Rac regulates ctin filament accumulation at the plasma membrane and Cdc42 stimulates formation of filopodia.
Anti-β-Actin (I102) Antibody from Bioworld Technology (AP0060) - Antibodies.com
For details please refer to datasheet.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.

A potential adjuvant chemotherapeutics, 18-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2. Sci Rep (2016) 6 : 25396

Lipoxin A4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells. Free Radic. Biol. Med. (2016) Apr 93 : 52-66

Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries. Sci Rep (2016) 6 : 19436

TSG attenuates LPC-induced endothelial cells inflammatory damage through notch signaling inhibition. IUBMB Life (2016) Jan 68 1: 37-50

Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes. Biochem. Pharmacol. (2016) Jan 15 100 : 98-111

Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment. J Neuroinflammation (2015) 12 1: 200

A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation. J Control Release (2015) Nov 28 218 : 29-35

Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9. Nutr Cancer (2015) 67 7: 1191-200

Tert-butylhydroquinone Ameliorates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Mice by Enhancing Nrf2-Independent Autophagy. Neurochem. Res. (2015) Sep 40 9: 1829-38

Comparative proteomic profiling and possible toxicological mechanism of acute injury induced by carbon ion radiation in pubertal mice testes. Reprod. Toxicol. (2015) Dec 58 : 45-53

Chronic Noise Exposure Acts Cumulatively to Exacerbate Alzheimer's Disease-Like Amyloid- Pathology and Neuroinflammation in the Rat Hippocampus. Sci Rep (2015) 5 : 12943

Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria. J. Proteome Res. (2015) Sep 4 14 9: 3645-57

Inhibition of SENP3 by lentivirus induces suppression of apoptosis in experimental subarachnoid hemorrhage in rats. Brain Res. (2015) Oct 5 1622 : 270-8

Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy. Pharmacol. Res. (2015) Sep 99 : 237-47

-Lipoic acid attenuates LPS-induced liver injury by improving mitochondrial function in association with GR mitochondrial DNA occupancy. Biochimie (2015) Sep 116 : 52-60

Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes. J. Lipid Res. (2015) Aug 56 8: 1471-80

Effect of HM910, a novel camptothecin derivative, on the inhibition of multiple myeloma cell growth in vitro and in vivo. Am J Cancer Res (2015) 5 3: 1000-16

Ginsenosides Regulate PXR/NF-B Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis. Drug Metab. Dispos. (2015) Aug 43 8: 1181-9

FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol. Lett. (2015) Jul 2 236 1: 43-59

GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKK. Cell. Signal. (2015) Jun 27 6: 1237-45

Protective effects of cholecystokinin-8 on methamphetamine-induced behavioral changes and dopaminergic neurodegeneration in mice. Behav. Brain Res. (2015) Apr 15 283 : 87-96

Stimulation of peroxisome proliferator-activated receptor inhibits estrogen receptor transcriptional activity in endometrial carcinoma cells. Oncol. Rep. (2015) Mar 33 3: 1227-34

Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Biochem. Cell Biol. (2015) Feb 93 1: 16-27

Changes in the proteomic profile during the differential polarization status of the human monocyte-derived macrophage THP-1 cell line. Proteomics (2015) Feb 15 4: 773-86

The effect of transportation of broilers during summer on the expression of heat shock protein 70, postmortem metabolism and meat quality. J. Anim. Sci. (2015) Jan 93 1: 62-70

2,3,5,4'-tetrahydroxystilbene-2-O--D-glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine-induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase. IUBMB Life (2014) Oct 66 10: 711-22

Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling. PLoS ONE (2014) 9 11: e112336

Identification of novel piRNAs in bladder cancer. Cancer Lett. (2015) Jan 28 356 2 Pt B: 561-7

Mesenchymal Stem Cells Overexpressing Angiotensin-Converting Enzyme 2 Rescue Lipopolysaccharide-Induced Lung Injury. Cell Transplant (2015) 24 9: 1699-715

Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc. Natl. Acad. Sci. U.S.A. (2014) Oct 21 111 42: E4504-12

MicroRNA-23a-3p attenuates oxidative stress injury in a mouse model of focal cerebral ischemia-reperfusion. Brain Res. (2014) Dec 10 1592 : 65-72

Overendocytosis of gold nanoparticles increases autophagy and apoptosis in hypoxic human renal proximal tubular cells. Int J Nanomedicine (2014) 9 : 4317-30

CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer. J. Cell. Biochem. (2015) Apr 116 4: 502-13

Hyperammonemia enhances the function and expression of P-glycoprotein and Mrp2 at the blood-brain barrier through NF-B. J. Neurochem. (2014) Dec 131 6: 791-802

NG as a novel nitric oxide donor induces apoptosis by increasing reactive oxygen species and inhibiting mitochondrial function in MGC803 cells. Int. Immunopharmacol. (2014) Nov 23 1: 27-36

Fluoxetine suppresses AMP-activated protein kinase signaling pathway to promote hepatic lipid accumulation in primary mouse hepatocytes. Int. J. Biochem. Cell Biol. (2014) Sep 54 : 236-44

Glucose dominates the regulation of carboxylesterases induced by lipopolysaccharide or interleukin-6 in primary mouse hepatocytes. Life Sci. (2014) Sep 1 112 2-Jan: 41-8

Long non-coding RNA HOTAIR promotes carcinogenesis and invasion of gastric adenocarcinoma. Biochem. Biophys. Res. Commun. (2014) Aug 22 451 2: 171-8

Neuropilin-1 promotes epithelial-to-mesenchymal transition by stimulating nuclear factor-kappa B and is associated with poor prognosis in human oral squamous cell carcinoma. PLoS ONE (2014) 9 7: e101931

The dipeptidyl peptidase-4 inhibitor sitagliptin protects against dyslipidemia-related kidney injury in Apolipoprotein E knockout mice. Int J Mol Sci (2014) 15 7: 11416-34

Phenotypic characterization of craniofacial bone marrow stromal cells: unique properties of enhanced osteogenesis, cell recruitment, autophagy, and apoptosis resistance. Cell Tissue Res. (2014) Oct 358 1: 165-75

Montelukast rescues primary neurons against A1-42-induced toxicity through inhibiting CysLT1R-mediated NF-B signaling. Neurochem. Int. (2014) Sep 75 : 26-31

Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism. Free Radic. Biol. Med. (2014) Aug 73 : 11-Jan

Maternal protein restriction during gestation and lactation programs offspring ovarian steroidogenesis and folliculogenesis in the prepubertal gilts. J. Steroid Biochem. Mol. Biol. (2014) Sep 143 : 267-76

Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells. J. Cell. Mol. Med. (2014) Jul 18 7: 1392-406

Proteasome inhibition-induced downregulation of Akt/GSK-3 pathway contributes to abnormality of tau in hippocampal slice. Mol. Neurobiol. (2014) Dec 50 3: 888-95

The mechanisms of 5-FU-PLA-O-CMC-NPS-mediated inhibition of the proliferation of colorectal cancer cell line SW480. Tumour Biol. (2014) Jun 35 6: 6095-103

mTOR-targeted therapy: differential perturbation to mitochondrial membrane potential and permeability transition pore plays a role in therapeutic response. Biochem. Biophys. Res. Commun. (2014) Apr 25 447 1: 184-91

Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions. Carbohydr Polym (2014) Jul 17 107 : 138-50

Induction of ROS-dependent mitochondria-mediated intrinsic apoptosis in MDA-MB-231 cells by glycoprotein from Codium decorticatum. J. Agric. Food Chem. (2014) Apr 16 62 15: 3410-21

Hydroxy-safflor yellow A attenuates A-induced inflammation by modulating the JAK2/STAT3/NF-B pathway. Brain Res. (2014) May 14 1563 : 72-80

Phosphorylation of heat shock protein 27 antagonizes TNF- induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cell. Signal. (2014) Jul 26 7: 1616-25

Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells. Free Radic. Res. (2014) May 48 5: 607-21

Granulocyte/macrophage colony-stimulating factor influences angiogenesis by regulating the coordinated expression of VEGF and the Ang/Tie system. PLoS ONE (2014) 9 3: e92691

Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE pathway. Free Radic. Biol. Med. (2014) Jun 71 : 186-95

Hemokinin-1(4-11)-induced analgesia selectively up-regulates -opioid receptor expression in mice. PLoS ONE (2014) 9 2: e90446

Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome. PLoS ONE (2014) 9 2: e89961

Activation of matrix metalloproteinase-26 by HOXA10 promotes embryo adhesion in vitro. Biochem. Biophys. Res. Commun. (2014) Mar 14 445 3: 622-8

Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF- release. Acta Pharmacol. Sin. (2014) Apr 35 4: 483-8

Sox9 potentiates BMP2-induced chondrogenic differentiation and inhibits BMP2-induced osteogenic differentiation. PLoS ONE (2014) 9 2: e89025

C-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis. Mol. Neurobiol. (2014) Apr 49 2: 1102-16

Cigarette smoke-induced alveolar epithelial-mesenchymal transition is mediated by Rac1 activation. Biochim. Biophys. Acta (2014) Jun 1840 6: 1838-49

Porcine glucocorticoid receptor (NR3C1) gene: tissue-specificity of transcriptional strength and glucocorticoid responsiveness of alternative promoters. J. Steroid Biochem. Mol. Biol. (2014) May 141 : 87-93

The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine IL-35 in apolipoprotein E-deficient mice. PLoS ONE (2014) 9 1: e87787

PTD-mediated intracellular delivery of mutant NFAT minimum DNA binding domain inhibited the proliferation of T cells. Int. Immunopharmacol. (2014) Mar 19 1: 110-8

Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice. Cell Death Dis (2014) 5 : e985

Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte. Int. Immunopharmacol. (2014) Feb 18 2: 365-72

Pretreatment with tert-butylhydroquinone attenuates cerebral oxidative stress in mice after traumatic brain injury. J. Surg. Res. (2014) May 1 188 1: 206-12

Upregulation of estrogen receptor mediates migration, invasion and proliferation of endometrial carcinoma cells by regulating the PI3K/AKT/mTOR pathway. Oncol. Rep. (2014) Mar 31 3: 1175-82

Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice. Mediators Inflamm. (2013) 2013 : 187873

Involvement of cysteinyl leukotriene receptor 1 in A1-42-induced neurotoxicity in vitro and in vivo. Neurobiol. Aging (2014) Mar 35 3: 590-9

Extracellular polysaccharide from Bacillus sp. strain LBP32 prevents LPS-induced inflammation in RAW 264.7 macrophages by inhibiting NF-B and MAPKs activation and ROS production. Int. Immunopharmacol. (2014) Jan 18 1: 12-9

Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy. Int. J. Mol. Med. (2014) Jan 33 1: 201-8

Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells. World J. Gastroenterol. (2013) Oct 7 19 37: 6265-71

MicroRNA-302b suppresses cell proliferation by targeting EGFR in human hepatocellular carcinoma SMMC-7721 cells. BMC Cancer (2013) 13 : 448

Curcumin modulates cannabinoid receptors in liver fibrosis in vivo and inhibits extracellular matrix expression in hepatic stellate cells by suppressing cannabinoid receptor type-1 in vitro. Eur. J. Pharmacol. (2013) Dec 5 721 1-3: 133-40

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice. J. Med. Chem. (2013) Oct 24 56 20: 7925-38

ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione. Int. J. Biochem. Cell Biol. (2013) Nov 45 11: 2632-42

Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. (2013) Dec 5 721 1-3: 355-64

Vaccination inhibits TLR2 transcription via suppression of GR nuclear translocation and binding to TLR2 promoter in porcine lung infected with Mycoplasma hyopneumoniae. Vet. Microbiol. (2013) Dec 27 167 3-4: 425-33

Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum. Reprod. (2013) Nov 28 11: 3074-85

FSH modulates the expression of inhibin-alpha and the secretion of inhibins via orphan nuclear receptor NUR77 in ovarian granulosa cells. Mol. Reprod. Dev. (2013) Sep 80 9: 734-43

CCAAT/enhancer-binding protein is involved in the breed-dependent transcriptional regulation of 3-hydroxysteroid dehydrogenase/(5)-(4)-isomerase in adrenal gland of preweaning piglets. J. Steroid Biochem. Mol. Biol. (2013) Nov 138 : 273-80

MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2. FEBS Lett. (2013) Aug 2 587 15: 2474-82

Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-B activation and HSP70 up-regulation. Toxicol. Lett. (2013) Aug 14 221 2: 73-82

In vitro to in vivo evidence of the inhibitor characteristics of Schisandra lignans toward P-glycoprotein. Phytomedicine (2013) Aug 15 20 11: 1030-8

Protective effect of -casomorphin-7 on cardiomyopathy of streptozotocin-induced diabetic rats via inhibition of hyperglycemia and oxidative stress. Peptides (2013) Jun 44 : 120-6

Sulfiredoxin-1 protects PC12 cells against oxidative stress induced by hydrogen peroxide. J. Neurosci. Res. (2013) Jun 91 6: 861-70

Estrogen deficiency inhibits the odonto/osteogenic differentiation of dental pulp stem cells via activation of the NF-B pathway. Cell Tissue Res. (2013) Jun 352 3: 551-9

Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-B and p38/JNK activation in microglial cells. Neurochem. Int. (2013) Jun 62 7: 913-21

Krppel-like factor 12 negatively regulates human endometrial stromal cell decidualization. Biochem. Biophys. Res. Commun. (2013) Mar 29 433 1: 11-7

Diammonium glycyrrhizinate attenuates A(1-42) -induced neuroinflammation and regulates MAPK and NF-B pathways in vitro and in vivo. CNS Neurosci Ther (2013) Feb 19 2: 117-24

Poly(ADP-ribose) polymerase inhibition protects epileptic hippocampal neurons from apoptosis via suppressing Akt-mediated apoptosis-inducing factor translocation in vitro. Neuroscience (2013) Feb 12 231 : 353-62

Development of rapid and highly sensitive HSPA1A promoter-driven luciferase reporter system for assessing oxidative stress associated with low-dose photodynamic therapy. Cell Stress Chaperones (2013) Mar 18 2: 203-13

Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology (2013) Jan 7 303 : 107-14

Fluoxetine induces hepatic lipid accumulation via both promotion of the SREBP1c-related lipogenesis and reduction of lipolysis in primary mouse hepatocytes. CNS Neurosci Ther (2012) Dec 18 12: 974-80

Neuropilin-1 down-regulation impairs cell migration and induces the differentiation of human tongue squamous cell carcinoma cells.

Effect of heparin-derived oligosaccharide on vascular smooth muscle cell proliferation and the signal transduction mechanisms involved. Cardiovasc Drugs Ther (2012) Dec 26 6: 479-88

Bog bilberry anthocyanin extract improves motor functional recovery by multifaceted effects in spinal cord injury. Neurochem. Res. (2012) Dec 37 12: 2814-25

Identification of urinary Gc-globulin as a novel biomarker for bladder cancer by two-dimensional fluorescent differential gel electrophoresis (2D-DIGE). J Proteomics (2012) Dec 21 77 : 225-36

NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway. Eur. J. Pharmacol. (2012) Sep 15 691 1-3: 61-8

Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer. Chem. Biol. Interact. (2012) Jul 30 199 1: 9-17

Identification of resting and type I IFN-activated human NK cell miRNomes reveals microRNA-378 and microRNA-30e as negative regulators of NK cell cytotoxicity. J. Immunol. (2012) Jul 1 189 1: 211-21

-actin as a loading control for plasma-based Western blot analysis of major depressive disorder patients. Anal. Biochem. (2012) Aug 15 427 2: 116-20

Quantitative proteomics using stable isotope labeling with amino acids in cell culture reveals protein and pathway regulation in porcine circovirus type 2 infected PK-15 cells. J. Proteome Res. (2012) Feb 3 11 2: 995-1008

(S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death. Neurochem. Int. (2012) Jan 60 2: 134-44

Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells. Mutat. Res. (2012) Mar 1 731 1-2: 75-84

miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP. Cancer Chemother. Pharmacol. (2012) Mar 69 3: 723-31

The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide. Toxicol. Lett. (2011) Sep 10 205 3: 320-6

The toxicity evaluation of nano-trititanate with bactericidal properties in vitro. Nanotoxicology (2012) May 6 3: 327-37

Total Citations (60)
Description: Mouse monoclonal antibody to β-Actin (4D3)
Application: WB, IHC
Host: Mouse
Reactivity: Human, Mouse, Rat Mammals
Immunogen: Recombinant full length Human β-Actin.

£220 – £366

Total Citations (6)
Description: Rabbit polyclonal antibody to β-Actin (D8)
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human β-Actin.

£157 – £269

Total Citations (4)
Description: Rabbit polyclonal antibody to β-Actin (I102)
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human β-Actin.

£157 – £269

Description: Mouse monoclonal (BA3R) antibody to β-Actin.
Application: Dot, ELISA, IS, WB
Host: Mouse
Isotype: IgG2b
Reactivity: Chicken, Human, Mouse, Rat, Rabbit.

£136 – £242

Please Note: Anti-β-Actin (I102) Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | AP0060
Size Price Quantity
50µl £157
100µl £269

Request a quotation
Contact Us Directly
  • call icon + 44 (0)1223 298 875
  • + 44 (0)1223 281 447
  • email icon info@antibodies.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Lead Time: Currently 5-7 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe