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Anti-BLNK Antibody

Mouse monoclonal antibody to BLNK from ABclonal (A0638).
Name: Anti-BLNK Antibody
Description: Mouse monoclonal antibody to BLNK.
Applications: WB
Dilutions: WB: 1:500 - 1:1000.
Reactivity: Human
Immunogen: A synthetic peptide of human BLNK.
Protein Length: 456
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Tissue Specificity: Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
Involvement in Disease: Agammaglobulinemia 4, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Post-Translational Modification: Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways.
Cellular Location: Cytoplasm. Cell membrane.

BCR activation results in the translocation to membrane fraction.
UniProt: Q8WV28
Gene ID: 29760
Synonyms: AGM4 Antibody
B cell adapter containing SH2 domain protein Antibody
B cell adapter containing Src homology 2 domain protein Antibody
B cell adaptor containing SH2 domain Antibody
B cell linker Antibody
B cell linker protein Antibody
B cell-specific adaptor protein Antibody
B-cell activation Antibody
B-cell adapter containing a SH2 domain protein Antibody
B-cell adapter containing a Src homology 2 domain protein Antibody
B-cell linker protein Antibody
BASH Antibody
Bca Antibody
BLNK s Antibody
BLNK_HUMAN Antibody
Cytoplasmic adapter protein Antibody
Ly 57 Antibody
Ly57 Antibody
Lymphocyte antigen 57 Antibody
Lyw 57 Antibody
Lyw57 Antibody
MGC111051 Antibody
SH2 domain-containing leukocyte protein, 65-KD Antibody
SLP 65 Antibody
SLP-65 Antibody
SLP65 Antibody
Src homology 2 domain containing leukocyte protein of 65 kDa Antibody
Src homology 2 domain-containing leukocyte protein of 65 kDa Antibody
Src homology [SH2] domain-containing leukocyte protein of 65 kD Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of NCI-H460 cell line, using BLNK antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to B-cell linker protein
Application: WB, IF
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 394 and 456 of BLNK

£301

Description: Rabbit polyclonal antibody to BLNK (Phospho-Tyr84)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of tyrosine 84 (E-M-Y(p)-V-M) derived from Human BLNK.

£180 – £234

Description: Goat polyclonal antibody to BLNK.
Application: ELISA, WB
Host: Goat
Isotype: IgG
Reactivity: Human

£205

Description: Rabbit polyclonal antibody to BLNK
Application: IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to residues near the C terminal of human B-cell linker

£234

Please Note: Anti-BLNK Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0638
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe