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Anti-C1 inh (SERPING1) Antibody

 
Mouse monoclonal (KT28) antibody to C1 inh (SERPING1) from Absea Biotechnology (020101F07).
Overview
Name: Anti-C1 inh (SERPING1) Antibody
Description: Mouse monoclonal (KT28) antibody to C1 inh (SERPING1).
Applications: ELISA
Reactivity: Human
Immunogen: Purified C1 inhibitor from human blood.
Host: Mouse
Clonality: Monoclonal
Clone: KT28
Isotype: IgG1
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target
Function: Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Involvement in Disease: Hereditary angioedema: An autosomal dominant disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. Hereditary angioedema due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In hereditary angioedema type 1, serum levels of C1 esterase inhibitor are decreased, while in type 2, the levels are normal or elevated, but the protein is non-functional.
Sequence Similarities: Belongs to the serpin family.
Post-Translational Modification: Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
Cellular Location: Secreted.
UniProt: P05155
Gene ID: 710
Synonyms: C1 esterase inhibitor Antibody
C1 Inactivator Antibody
C1 inhibiting factor Antibody
C1 inhibitor Antibody
C1-inhibiting factor Antibody
C1IN Antibody
C1Inh Antibody
C1NH Antibody
complement component 1 inhibitor Antibody
esterase inhibitor Antibody
HAE1 Antibody
HAE2 Antibody
IC1_HUMAN Antibody
Plasma protease C1 inhibitor Antibody
Serine (or cysteine) proteinase inhibitor clade G member 1 Antibody
serine/cysteine proteinase inhibitor clade G member 1 Antibody
Serpin G1 Antibody
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 Antibody
SERPING1 Antibody
Information: Target information shown above is from the UniProt Consortium.


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Product Citations (1)
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Please Note: Anti-C1 inh (SERPING1) Antibody is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | 020101F07
Size Price Quantity
100µg £178
200µg £259
1mg £682

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