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Anti-Cathepsin D Antibody

Rabbit polyclonal antibody to Cathepsin D from ABclonal (A0041).
Name: Anti-Cathepsin D Antibody
Description: Rabbit polyclonal antibody to Cathepsin D.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:50.
Reactivity: Human
Immunogen: A synthetic peptide of human CTSD.
Protein Length: 412
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Tissue Specificity: Expressed in the aorta extrcellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
Involvement in Disease: Ceroid lipofuscinosis, neuronal, 10: A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
Sequence Similarities: Belongs to the peptidase A1 family.
Post-Translational Modification: N- and O-glycosylated.
Cellular Location: Lysosome. Melanosome. Secreted > Extracellular space.

Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
UniProt: P07339
Gene ID: 1509
Synonyms: CatD Antibody
CATD_HUMAN Antibody
Cathepsin D heavy chain Antibody
CD Antibody
Ceroid lipofuscinosis neuronal 10 Antibody
CLN10 Antibody
CPSD Antibody
ctsd Antibody
Epididymis secretory sperm binding protein Li 130P Antibody
HEL S 130P Antibody
Lysosomal aspartyl peptidase Antibody
Lysosomal aspartyl protease Antibody
MGC2311 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of HepG2 cell line, using CTSD antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to CTSD
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant Protein of human CTSD.

£234

Description: Rabbit polyclonal antibody to CTSD.
Application: WB, IHC, IF
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Description: Rabbit polyclonal antibody to cathepsin D
Application: WB, IHC
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 72 and 262 of Human CTSD

£301

Description: Rabbit polyclonal antibody to Cathepsin D (HC)
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human Cathepsin D (Heavy chain).

£165 – £283

Please Note: Anti-Cathepsin D Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0041
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe