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Anti-CD130 Antibody

Rabbit polyclonal antibody to CD130 from ABclonal (A0469).
Name: Anti-CD130 Antibody
Description: Rabbit polyclonal antibody to CD130.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:100.
Reactivity: Human
Immunogen: A synthetic peptide of human IL6ST.
Protein Length: 918
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
Tissue Specificity: Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Sequence Similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.
Post-Translational Modification: Phosphorylation of Ser-782 down-regulates cell surface expression.
Cellular Location: Cell membrane.
UniProt: P40189
Gene ID: 3572
Synonyms: CD130 (gp130) Antibody
CD130 antigen Antibody
CDw130 Antibody
gp130 Antibody
GP130 RAPS Antibody
IL 6R beta Antibody
IL-6 receptor subunit beta Antibody
IL-6R subunit beta Antibody
IL-6R-beta Antibody
IL-6RB Antibody
IL6 ST Antibody
IL6RB_HUMAN Antibody
IL6ST Antibody
Interleukin 6 receptor subunit beta Antibody
Interleukin receptor beta chain Antibody
Interleukin-6 receptor subunit beta Antibody
Interleukin-6 signal transducer Antibody
Membrane glycoprotein 130 Antibody
Membrane glycoprotein gp130 Antibody
Oncostatin M receptor Antibody
Oncostatin M receptor alpha subunit Antibody
Oncostatin-M receptor subunit alpha Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of MDA-MB231 cell lines, using IL6ST antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (2)
Description: Rabbit polyclonal antibody to gp130 (S778)
Application: WB, IHC, IF
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide, corresponding to amino acids 750-800 of Human gp130.

£165 – £283

Description: Rabbit Polycolonal antibody to CD130 / gp130 (Phospho-Ser782)
Application: WB
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: A synthesized peptide derived from human CD130 / gp130 (Phospho-Ser782)

£180 – £234

Description: Rabbit polyclonal antibody to CD130
Application: WB, IHC, IF, ELISA
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthesized peptide derived from human CD130 around the non-phosphorylation site of S782.

£180 – £234

Description: Rabbit Polycolonal antibody to gp130 (Phospho-Tyr759)
Application: WB
Host: Rabbit
Reactivity: Human, Rat
Immunogen: A synthesized peptide derived from human gp130 (Phospho-Tyr759)

£180 – £234

Please Note: Anti-CD130 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0469
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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