|Description:||Rabbit polyclonal antibody to CD45.|
|Applications:||WB, IHC, FC|
|Dilutions:||WB: 1:200 - 1:500, IHC: 1:50 - 1:100, FC: 1:20 - 1:50.|
|Immunogen:||A synthetic peptide of human PTPRC.|
|Formulation:||Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).|
|Involvement in Disease:||Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Multiple sclerosis: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
|Sequence Similarities:||Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.|
|Post-Translational Modification:||Heavily N- and O-glycosylated.|
|Cellular Location:||Membrane. Membrane raft.
Colocalized with DPP4 in membrane rafts.
CD 45 Antibody
CD45 antigen Antibody
EC 22.214.171.124 Antibody
L CA Antibody
Leukocyte common antigen Antibody
Leukocyte common antigen precursor Antibody
LY 5 Antibody
Ly5, homolog of Antibody
Lymphocyte antigen 5 Antibody
Protein tyrosine phosphatase receptor type C Antibody
Protein tyrosine phosphatase receptor type c polypeptide Antibody
protein tyrosine phosphatase, receptor type, C Antibody
Protein tyrosine phosphatase, receptor type, c polypeptide Antibody
Receptor type tyrosine protein phosphatase C Antibody
Receptor-type tyrosine-protein phosphatase C Antibody
T200 glycoprotein Antibody
T200 leukocyte common antigen Antibody
|Information:||Target information shown above is from the UniProt Consortium.|