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Anti-CD63 Antibody

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Total Citations (39)
Mouse monoclonal (MEM-259) antibody to CD63 from Exbio (11-343).

   Please Note: This is exactly the same antibody that is marketed as:


 
   •  Abcam | ab8219
   •  Novus Biologicals | NB100-77913
Name: Anti-CD63 Antibody
Description: Mouse monoclonal (MEM-259) antibody to CD63.
Specificity: The antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.
Applications: FC, IP, IHC-P, ICC
Reactivity: Human
Immunogen: HPB-ALL T cell line.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-259
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Introduction: CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. It is also present in the plasma membrane, usually following cell activation. Hence, it has become an widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas.
Synonyms: Lysosomal associated membrane protein 3 Antibody
CD 63 Antibody
CD63 antigen Antibody
CD63 antigen (melanoma 1 antigen) Antibody
CD63 antigen melanoma 1 antigen Antibody
CD63 molecule Antibody
CD63_HUMAN Antibody
gp55 Antibody
Granulophysin Antibody
LAMP 3 Antibody
LAMP-3 Antibody
LAMP3 Antibody
LIMP Antibody
Lysosomal-associated membrane protein 3 Antibody
Lysosome associated membrane glycoprotein 3 Antibody
Mast cell antigen AD1 Antibody
ME491 Antibody
Melanoma 1 antigen Antibody
Melanoma associated antigen ME491 Antibody
Melanoma associated antigen MLA1 Antibody
Melanoma-associated antigen ME491 Antibody
MGC72893 Antibody
MLA 1 Antibody
MLA1 Antibody
NGA Antibody
Ocular melanoma associated antigen Antibody
Ocular melanoma-associated antigen Antibody
OMA81H Antibody
PTLGP40 Antibody
Tetraspanin 30 Antibody
Tetraspanin-30 Antibody
Tspan 30 Antibody
Tspan-30 Antibody
TSPAN30 Antibody

   Please Note: These publications cite this antibody under different brand names & catalogue numbers.


Cites ab8219

Yang Y  et al. Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of a-synuclein via exosome. PLoS One 12:e0180892 (2017).

Cites ab8219

Su Y  et al. PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1. Sci Rep 7:39701 (2017).

Cites ab8219

Mehta A  et al. Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate. EMBO Mol Med 8:1380-1389 (2016).

Cites ab8219

Hildonen S  et al. Isolation and mass spectrometry analysis of urinary extraexosomal proteins. Sci Rep 6:36331 (2016).

Cites ab8219

Jethwa SA  et al. Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells. J Cell Sci 129:3948-3957 (2016).

Cites ab8219

Sinha S  et al. Cortactin promotes exosome secretion by controlling branched actin dynamics. J Cell Biol 214:197-213 (2016).

Cites ab8219

Alford JE  et al. Human Immunodeficiency Virus Type 2 (HIV-2) Gag Is Trafficked in an AP-3 and AP-5 Dependent Manner. PLoS One 11:e0158941 (2016).

Cites ab8219

Kushner EJ  et al. Excess Centrosomes Perturb Dynamic Endothelial Cell Repolarization During Blood Vessel Formation. Mol Biol Cell N/A:N/A (2016).

Cites ab8219

Weilner S  et al. Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles. Aging (Albany NY) 8:16-33 (2016).

Cites ab8219

Lobb RJ  et al. Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles 4:27031 (2015).

Cites ab8219

Bala S  et al. Biodistribution and function of extracellular miRNA-155 in mice. Sci Rep 5:10721 (2015).

Cites ab8219

Trerotola M  et al. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Oncotarget 6:14318-28 (2015).

Cites ab8219

Bumrungthai S  et al. Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues. PLoS One 10:e0127109 (2015).

Cites NB100-77913

Fong MY, Zhou W, Liu L et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis Nat. Cell Biol. 2015 Feb 01

Cites ab8219

Van Deun J  et al. The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling. J Extracell Vesicles 3:N/A (2014).

Cites ab8219

Bukong TN  et al. Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90. PLoS Pathog 10:e1004424 (2014).

Cites NB100-77913

Chow A, Zhou W, Liu L et al. Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-kB. Sci Rep 2014 Jul 18

Cites ab8219

Esposito L  et al. Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles. J Immunol 193:889-900 (2014).

Cites ab8219

Salomon C  et al. A gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migration. PLoS One 9:e98667 (2014).

Cites ab8219

Ahmed W  et al. Epstein-Barr Virus-Encoded Small RNAs (EBERs) Are Present in Fractions Related to Exosomes Released by EBV-Transformed Cells. PLoS One 9:e99163 (2014).

Cites ab8219

Nardacci R  et al. Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients. Autophagy 10:1167-78 (2014).

Cites ab8219

Vargas A  et al. Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia. FASEB J 28:3703-19 (2014).

Cites ab8219

Sade H  et al. A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding. PLoS One 9:e96340 (2014).

Cites ab8219

Ghossoub R  et al. Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2. Nat Commun 5:3477 (2014).

Cites ab8219

Zhang Z  et al. Valproic acid causes proteasomal degradation of DICER and influences miRNA expression. PLoS One 8:e82895 (2013).

Cites ab8219

Salomon C  et al. Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes. PLoS One 8:e79636 (2013).

Cites ab8219

He J  et al. Dual function of CD81 in influenza virus uncoating and budding. PLoS Pathog 9:e1003701 (2013).

Cites ab8219

Christianson HC  et al. Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proc Natl Acad Sci U S A 110:17380-5 (2013).

Cites ab8219

Narayanan A  et al. Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA. J Biol Chem 288:20014-33 (2013).

Cites ab8219

Svensson KJ  et al. Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem 288:17713-24 (2013).

Cites ab8219

Shimizu C  et al. Differential expression of miR-145 in children with Kawasaki disease. PLoS One 8:e58159 (2013).

Cites ab8219

Baietti MF  et al. Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat Cell Biol : (2012).

Cites ab8219

Lv LH  et al. Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell anti-tumor responses in vitro. J Biol Chem : (2012).

Cites ab8219

Duchez S  et al. Reciprocal polarization of T and B cells at the immunological synapse. J Immunol 187:4571-80 (2011).

Cites NB100-77913

Yoon SO et al. Am. J. Pathol. 177:377. 2010

Cites ab8219

Ashiru O  et al. Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res 70:481-9 (2010).

Cites NB100-77913

Schmidt H et al. BMC Immunol. 10:41. 2009

Cites NB100-77913

Wang X et al. Infect. Immun. 74:1873. 2006

Cites NB100-77913

Kishimoto T et al. Leucocyte Typing VI. Garland Publishing Inc. London. Eds. 1997.

Rating

Species

Application

Date

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Human

ICC/IF

26-Sep-2014

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Human

Flow Cytometry

29-Sep-2010

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Human

Flow Cytometry

22-Sep-2009

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Human

ICC/IF

25-Aug-2009


Total Citations (5)
Description: Rabbit polyclonal antibody to CD63 (K156)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 111-160 of Human CD63.

£165 – £283

Description: Rabbit polyclonal antibody to LAMP3.
Application: WB, IHC
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Description: Rabbit polyclonal antibody to LAMP3
Application: WB, IHC
Host: Rabbit
Reactivity: Human
Immunogen: A synthetic peptide of human LAMP3.

£234

Total Citations (1)
Description: Mouse monoclonal antibody to CD63 (8H2)
Application: WB
Host: Mouse
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human CD63.

£220 – £366

Please Note: Anti-CD63 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | 11-343
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100µg £148

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