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Anti-CD8a Antibody

 
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Total Citations (11)
Rat monoclonal (53-6.7) antibody to CD8a from Antibodies.com (A86749).

   Please Note: This is exactly the same antibody that is marketed as:


 
   •  Abcam | ab25478
   •  Novus Biologicals | MAB116 | NBP1-49045
Name: Anti-CD8a Antibody
Description: Rat monoclonal (53-6.7) antibody to CD8a.
Specificity: The rat monoclonal antibody 53-6.7 recognizes mouse CD8a (32-34 kDa; alpha chain of the CD8 antigen).
Applications: FC, IP, IHC-P, IHC-Fr, ICC, FUNC
Reactivity: Mouse
Immunogen: Mouse spleen cells.
Host: Rat
Clonality: Monoclonal
Clone: 53-6.7
Isotype: IgG2a
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Introduction: The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Synonyms: CD8 Antibody
CD8 antigen, alpha polypeptide (p32) Antibody
CD8a antigen Antibody
CD8a molecule Antibody
CD8A_HUMAN Antibody
Leu2 Antibody
Leu2 T lymphocyte antigen Antibody
MAL Antibody
OKT8 T cell antigen Antibody
p32 Antibody
T cell antigen Leu2 Antibody
T cell co receptor Antibody
T-cell surface glycoprotein CD8 alpha chain Antibody
T-lymphocyte differentiation antigen T8/Leu-2 Antibody
T8 T cell antigen Antibody

   Please Note: These publications cite this antibody under different brand names & catalogue numbers.


Cites NBP1-49045

Ledbetter JA, Herzenberg LA. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev. 1979

Cites NBP1-49045

Sierra RA, Trillo-Tinoco J, Mohamed E et al. Anti-Jagged immunotherapy inhibits MDSCs and overcomes tumor-induced tolerance Cancer Res. 2017 Sep 13

Cites NBP1-49045

Cohen N, Shani O, Raz Y et al. Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1. Oncogene. Apr 3 2017

Cites NBP1-49045

Li A, Wu Y, Tang F et al. In Vivo Magnetic Resonance Imaging of CD8+ T Lymphocytes Recruiting to Glioblastoma in Mice. Cancer Biother. Radiopharm. Nov 1 2016

Cites MAB116

Zhang, Hanwei, Chin, Arnold I Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. PLoS ONE, 2014;9(4):e94793. 2014

Cites NBP1-49045

Fazio F, Zappulla C, Notartomaso S et al. Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice. Neuropharmacology 2014 Mar 3

Cites NBP1-49045

KheradmT, Wang S, Gibly R et al. Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions Biomaterials 2011 Jul

Cites NBP1-49045

Bankoti J, Burnett A, Navarro S et al. Effects of TCDD on the fate of naive dendritic cells. Toxicol Sci. 2010 Jun.

Cites MAB116

Hokeness KL, Deweerd ES, Munks MW, Lewis CA, Gladue RP, Salazar-Mather TP CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection. J. Virol., 2007;81(3):1241-50. 2007

Cites NBP1-49045

Takahashi K, Nakata M, Tanaka T et al. CD4 and CD8 regulate interleukin 2 responses of T cells. Proc Natl Acad Sci U S A. 1992 Jun.

Cites NBP1-49045

McLellan AD, Kapp M, Eggert A et al. Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression. Blood.

Rating

Species

Application

Date

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Mouse

IHC-P

23-Oct-2017

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Mouse

IHC-Fr

03-Mar-2017

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Mouse

IHC-P

15-Dec-2014


start icons start icons start icons start icons start icons (2)
Total Citations (10)
Description: Mouse monoclonal (OX-8) antibody to CD8a.
Application: FC, IP, WB, IHC-P, IHC-Fr, FUNC
Host: Mouse
Isotype: IgG1
Reactivity: Rat

£148





start icons start icons start icons start icons start icons (1)
Total Citations (2)
Description: Rat monoclonal (53-6.7) antibody to CD8a.
Application: FC, IP, IHC-P, IHC-Fr, ICC, FUNC
Host: Rat
Isotype: IgG2a
Reactivity: Mouse

£129





Description: Rabbit polyclonal antibody to CD8A
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human CD8A.

£165 – £283

Please Note: Anti-CD8a Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A86749
Size Price Quantity
100µg £129

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