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Anti-CD8a Antibody

 
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Total Citations (2)
Rat monoclonal (53-6.7) antibody to CD8a from Antibodies.com (A86753).

   Please Note: This is exactly the same antibody that is marketed as:


 
   •  Novus Biologicals | MAB116
Name: Anti-CD8a Antibody
Description: Rat monoclonal (53-6.7) antibody to CD8a.
Specificity: The rat monoclonal antibody 53-6.7 recognizes mouse CD8a (32-34 kDa; alpha chain of the CD8 antigen).
Applications: FC, IP, IHC-P, IHC-Fr, ICC, FUNC
Reactivity: Mouse
Immunogen: Mouse spleen cells.
Host: Rat
Clonality: Monoclonal
Clone: 53-6.7
Isotype: IgG2a
Conjugate: Unconjugated
Purification: Protein G chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 µm filter sterilised). Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
Storage: Store at 2-8°C.
Introduction: The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Synonyms: CD8 Antibody
CD8 antigen, alpha polypeptide (p32) Antibody
CD8a antigen Antibody
CD8a molecule Antibody
CD8A_HUMAN Antibody
Leu2 Antibody
Leu2 T lymphocyte antigen Antibody
MAL Antibody
OKT8 T cell antigen Antibody
p32 Antibody
T cell antigen Leu2 Antibody
T cell co receptor Antibody
T-cell surface glycoprotein CD8 alpha chain Antibody
T-lymphocyte differentiation antigen T8/Leu-2 Antibody
T8 T cell antigen Antibody

   Please Note: These publications cite this antibody under different brand names & catalogue numbers.


Cites MAB116

Zhang, Hanwei, Chin, Arnold I Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. PLoS ONE, 2014;9(4):e94793. 2014

Cites MAB116

Hokeness KL, Deweerd ES, Munks MW, Lewis CA, Gladue RP, Salazar-Mather TP CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection. J. Virol., 2007;81(3):1241-50. 2007

Rating

Species

Application

Date

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Mouse

IHC-Fr

03-Mar-2017


start icons start icons start icons start icons start icons (3)
Total Citations (11)
Description: Rat monoclonal (53-6.7) antibody to CD8a.
Application: FC, IP, IHC-P, IHC-Fr, ICC, FUNC
Host: Rat
Isotype: IgG2a
Reactivity: Mouse

£129





start icons start icons start icons start icons start icons (2)
Total Citations (10)
Description: Mouse monoclonal (OX-8) antibody to CD8a.
Application: FC, IP, WB, IHC-P, IHC-Fr, FUNC
Host: Mouse
Isotype: IgG1
Reactivity: Rat

£148





Description: Rabbit polyclonal antibody to CD8A
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human CD8A.

£165 – £283

Please Note: Anti-CD8a Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A86753
Size Price Quantity
100µg £129

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