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Anti-CDC25A Antibody

Rabbit polyclonal antibody to CDC25A from ABclonal (A0896).
Name: Anti-CDC25A Antibody
Description: Rabbit polyclonal antibody to CDC25A.
Applications: WB
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human
Immunogen: A synthetic peptide of human CDC25A.
Protein Length: 524
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Sequence Similarities: Belongs to the MPI phosphatase family.
Post-Translational Modification: Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.
UniProt: P30304
Gene ID: 993
Synonyms: Cdc 25a Antibody
CDC25A2 Antibody
CDC25A2 CAG isoform Antibody
Cell division cycle 25 homolog A (S. pombe) Antibody
Cell division cycle 25A Antibody
Cell division cycle 25A isoform a Antibody
Cell division cycle 25A isoform b Antibody
D9Ertd393e Antibody
Dual specificity phosphatase Cdc25A Antibody
M phase inducer phosphatase 1 Antibody
M-phase inducer phosphatase 1 Antibody
MGC115549 Antibody
MPIP1_HUMAN Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of NIH-3T3 cell line, using CDC25A antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to CDC25A.
Application: WB, IHC
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Total Citations (1)
Description: Rabbit polyclonal antibody to cdc25A (Phospho-Ser76)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of serine 76 (M-G-S(p)-S-E) derived from Human cdc25A.

£180 – £234

Total Citations (2)
Description: Rabbit polyclonal antibody to Cdc25A
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human Cdc25A.

£220 – £366

Description: Rabbit polyclonal antibody to CDC25A
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human CDC25A.

£234

Please Note: Anti-CDC25A Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0896
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe