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Anti-cdc42 Antibody

Rabbit polyclonal antibody to cdc42 from ABclonal (A0078).
Name: Anti-cdc42 Antibody
Description: Rabbit polyclonal antibody to cdc42.
Applications: WB, FC
Dilutions: WB: 1:500 - 1:1000, FC: 1:20 - 1:50.
Reactivity: Human
Immunogen: A synthetic peptide of human CDC42.
Protein Length: 191
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity).
Involvement in Disease: Takenouchi-Kosaki syndrome: A syndrome characterized by macrothrombocytopenia, lymphedema, mental retardation, developmental delay, and distinctive facial features.
Sequence Similarities: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
Post-Translational Modification: (Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
Cellular Location: Cell membrane. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle. Midbody.

Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.
UniProt: P60953
Gene ID: 998
Synonyms: CDC42Hs Antibody
CDC42_HUMAN Antibody
Cell division control protein 42 homolog Antibody
Cell division cycle 42 Antibody
Cell division cycle 42 (GTP binding protein 25kDa) Antibody
dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)) Antibody
dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)) Antibody
G25K Antibody
G25K GTP-binding protein Antibody
Growth regulating protein Antibody
GTP binding protein 25kDa Antibody
Small GTP binding protein CDC42 Antibody
TKS Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of A431 cells, using CDC42 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to CDC42
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human CDC42.

£234

Total Citations (1)
Description: Rabbit polyclonal antibody to Cdc42
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human Cdc42.

£220 – £366

Description: Rabbit polyclonal antibody to CDC42.
Application: WB, IHC
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Description: Rabbit polyclonal antibody to CDC42 / RHO / RAC
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human Cell division cycle 42

£234

Please Note: Anti-cdc42 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0078
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe