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Anti-CHTOP (FOP) Antibody

 
Rat monoclonal (KT64) antibody to CHTOP (FOP) from Absea Biotechnology (110207C04).
Overview
Name: Anti-CHTOP (FOP) Antibody
Description: Rat monoclonal (KT64) antibody to CHTOP (FOP).
Applications: WB, IP, IHC, IF
Reactivity: Mouse
Immunogen: The C-terminal fragment of mouse CHTOP.
Amino Acid Start: 177
Amino Acid End: 420
Host: Rat
Clonality: Monoclonal
Clone: KT64
Isotype: IgG2a
Conjugate: Unconjugated
Purification: Antibody is purified from culture supernatant using a protein G column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target
Function: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789).
Tissue Specificity: Broadly expressed with highest levels found in thymus, spleen, and lymph nodes. Expressed in an erythroid progenitor cell line derived from fetal liver.
Post-Translational Modification: Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5.
Cellular Location: Nucleus. Nucleus > Nucleolus. Nucleus > Nucleoplasm. Nucleus speckle.

Mostly associated with facultative heterochromatin. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By similarity).
UniProt: Q9CY57
Gene ID: 66511
Synonyms: C1orf77 Antibody
chromatin target of chromatin target of PRMT1 protein Antibody
Chromatin target of PRMT1 Antibody
Chromatin target of PRMT1 protein Antibody
Chromosome 1 open reading frame 77 Antibody
CHTOP_HUMAN Antibody
DKFZp547E1010 Antibody
FL- RP1-178F15.2 Antibody
FL-SRAG Antibody
FOP Antibody
Friend of PRMT1 Antibody
Friend of PRMT1 protein Antibody
HT031 Antibody
MGC131924 Antibody
MGC86949 Antibody
OTTHUMP00000035122 Antibody
OTTHUMP00000035123 Antibody
Pp7704 Antibody
RP1 178F15.2 Antibody
Small arginine- and glycine-rich protein Antibody
Small protein rich in arginine and glycine Antibody
SRAG Antibody
SRAG-3 Antibody
SRAG-5 Antibody
Information: Target information shown above is from the UniProt Consortium.

Specific Citations

Papadopoulos P et al. A dual reporter mouse model of the human beta-globin locus: applications and limitations. PLoS One 7(12): e51272 (2012)

Fanis P et al. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Mol Cell Proteomics 11(11): 1263-73 (2012)

van Dijk TB et al. Fetal globin expression is regulated by Friend of Prmt1. Blood 116(20): 4349-52 (2010)

van Dijk TB et al. Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. Mol. Cell. Biol. 30(1): 260 - 272 (2010)



Related Products
Product Citations (1)
Description: Rat monoclonal (KT59) antibody to CHTOP (FOP).
Application: WB, IP, IHC
Host: Rat
Isotype: IgG2a
Reactivity: Mouse

£186 – £730





Description: Rabbit Polyclonal Antibody to C1orf77
Application: ELISA, WB
Host: Rabbit
Isotype: IgG
Immunogen: chromosome 1 open reading frame 77

£241






Please Note: Anti-CHTOP (FOP) Antibody is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | 110207C04
Size Price Quantity
100µg £186
200µg £273
1mg £730

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