Anti-CHTOP (FOP) Antibody
Rat monoclonal (KT64) antibody to CHTOP (FOP) from Absea Biotechnology (110207C04).
|Name:||Anti-CHTOP (FOP) Antibody|
|Description:||Rat monoclonal (KT64) antibody to CHTOP (FOP).|
|Applications:||WB, IP, IHC, IF|
|Immunogen:||The C-terminal fragment of mouse CHTOP.|
|Amino Acid Start:||177|
|Amino Acid End:||420|
|Purification:||Antibody is purified from culture supernatant using a protein G column.|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789).|
|Tissue Specificity:||Broadly expressed with highest levels found in thymus, spleen, and lymph nodes. Expressed in an erythroid progenitor cell line derived from fetal liver.|
|Post-Translational Modification:||Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5.|
|Cellular Location:||Nucleus. Nucleus > Nucleolus. Nucleus > Nucleoplasm. Nucleus speckle.
Mostly associated with facultative heterochromatin. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By similarity).
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|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-CHTOP (FOP) Antibody is for research use only. It is not intended for diagnostic of therapeutic use.