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Anti-Cortactin Antibody

Rabbit polyclonal antibody to Cortactin from ABclonal (A0841).
Name: Anti-Cortactin Antibody
Description: Rabbit polyclonal antibody to Cortactin.
Applications: WB, IHC
Dilutions: WB: 1:1000 - 1:2000, IHC: 1:50 - 1:100.
Reactivity: Human
Immunogen: A synthetic peptide of human CTTN.
Protein Length: 550(513)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
Post-Translational Modification: Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.
Cellular Location: Cytoplasm > Cytoskeleton. Cell projection > Lamellipodium. Cell projection > Ruffle. Cell projection > Dendrite. Cell projection. Cell membrane. Cell projection > Podosome. Cell junction. Cell junction > Focal adhesion. Membrane > Clathrin-coated pit. Cell projection > Dendritic spine. Cytoplasm > Cell cortex.

Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity).
UniProt: Q14247
Gene ID: 2017
Synonyms: Amplaxin Antibody
CTTN Antibody
EMS 1 Antibody
EMS1 Antibody
FLJ34459 Antibody
Mammary tumor and squamous cell carcinoma associated Antibody
Oncogene EMS1 Antibody
p80/85 src substrate Antibody
Src substrate cortactin Antibody
SRC8_HUMAN Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of HeLa cell line, using CTTN antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Total Citations (2)
Description: Goat polyclonal antibody to CTTN.
Application: ELISA, WB
Host: Goat
Isotype: IgG
Reactivity: Human, Mouse, Rat

£205

Total Citations (1)
Description: Rabbit polyclonal antibody to Cortactin (Ab-466)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Peptide sequence around aa.464~468 (P-V-Y-E-T) derived from Human CORTACTIN.

£180 – £234

Description: Rabbit polyclonal antibody to Cortactin (Acetyl-Lys235)
Application: WB, ELISA
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the Internal region of human Cortactin around the acetylation site of K235.

£180 – £234

Description: Rabbit polyclonal antibody to Cortactin (P415)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 382-432 of Human Cortactin.

£165 – £283

Please Note: Anti-Cortactin Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0841
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
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  • £20 to United Kingdom
  • £35 to Europe