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Anti-DNMT3A Antibody

Rabbit polyclonal antibody to DNMT3A from ABclonal (A0193).
Name: Anti-DNMT3A Antibody
Description: Rabbit polyclonal antibody to DNMT3A.
Applications: WB, IHC
Dilutions: WB: 1:200 - 1:500.
Reactivity: Human
Immunogen: Recombinant protein of human DNMT3A.
Protein Length: 912
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Tissue Specificity: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Involvement in Disease: Tatton-Brown-Rahman syndrome: An overgrowth syndrome characterized by a distinctive facial appearance, tall stature and intellectual disability. Facial gestalt is characterized by a round face, heavy horizontal eyebrows and narrow palpebral fissures. Less common features include atrial septal defects, seizures, umbilical hernia, and scoliosis.
Sequence Similarities: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Post-Translational Modification: Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.
Cellular Location: Nucleus. Cytoplasm.

Accumulates in the major satellite repeats at pericentric heterochromatin.
UniProt: Q9Y6K1
Gene ID: 1788
Synonyms: DNA (cytosine 5) methyltransferase 3 alpha Antibody
DNA (cytosine 5) methyltransferase 3A Antibody
DNA (cytosine-5)-methyltransferase 3A Antibody
DNA cytosine methyltransferase 3A2 Antibody
DNA methyltransferase 3 alpha Antibody
DNA methyltransferase 3a Antibody
DNA methyltransferase HsaIIIA Antibody
DNA MTase HsaIIIA Antibody
DNM3A_HUMAN Antibody
DNMT Antibody
DNMT 3a Antibody
DNMT3A2 Antibody
M.HsaIIIA Antibody
MCMT Antibody
OTTHUMP00000201149 Antibody
TBRS Antibody
Information: Target information shown above is from the UniProt Consortium.
Total Citations (1)
Description: Rabbit polyclonal antibody to DNMT3A
Application: WB, IHC, IF, IP
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human DNMT3A.

£220 – £366

Description: Rabbit monoclonal antibody to DNMT3A
Application: WB, ICC/IF
Host: Rabbit
Reactivity: Human, Rat
Immunogen: Recombinant antibody.

£269 – £400

Description: Rabbit polyclonal antibody to DNMT3A
Application: WB, IHC, IF, IP
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human DNMT3A.

£234

Description: Rabbit monoclonal antibody to Dnmt3a.
Application: WB, IF
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat

£372 – £565

Please Note: Anti-DNMT3A Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0193
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe