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Anti-FGF1 (aFGF) Antibody

Rat monoclonal (KT115) antibody to FGF1 from Absea Biotechnology (031116C06).
Name: Anti-FGF1 (aFGF) Antibody
Description: Rat monoclonal (KT115) antibody to FGF1.
Applications: WB, ELISA 
Reactivity: Human
Immunogen: Recombinant human aFGF.
Host: Rat
Clonality: Monoclonal
Clone: KT115
Isotype: IgG2a
Conjugate: Unconjugated
Purification: IgG is purified through a Protein G column.
Concentration: 1 mg/ml
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
Tissue Specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Sequence Similarities: Belongs to the heparin-binding growth factors family.
Post-Translational Modification: In the nucleus, phosphorylated by PKC/PRKCD.
Cellular Location: Secreted. Cytoplasm. Cytoplasm > Cell cortex. Cytoplasm > Cytosol. Nucleus.

Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
UniProt: P05230
Gene ID: 2246
Synonyms: Acidic fibroblast growth factor Antibody
aFGF Antibody
Beta endothelial cell growth factor Antibody
Beta-endothelial cell growth factor Antibody
ECGF Antibody
ECGF beta Antibody
ECGF-beta Antibody
ECGFA Antibody
ECGFB Antibody
Endothelial Cell Growth Factor alpha Antibody
Endothelial Cell Growth Factor beta Antibody
FGF 1 Antibody
FGF alpha Antibody
FGF1_HUMAN Antibody
FGFA Antibody
Fibroblast growth factor 1 Antibody
Fibroblast Growth Factor 1 Acidic Antibody
GLIO703 Antibody
HBGF 1 Antibody
HBGF-1 Antibody
HBGF1 Antibody
Heparin binding growth factor 1 Antibody
Heparin binding growth factor 1 precursor Antibody
Heparin-binding growth factor 1 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blotting result.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to FGF1.
Application: WB, IHC
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Description: Rabbit polyclonal antibody to FGF1 (H56)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide, corresponding to amino acids 21-70 of Human FGF-1.

£165 – £283

Description: Rabbit polyclonal antibody to FGF1
Application: IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human Fibroblast growth factor 1


Description: Rabbit polyclonal antibody to Fibroblast growth factor 1
Application: WB
Host: Rabbit
Reactivity: Mouse
Immunogen: Recombinant mouse Fibroblast growth factor 1 protein


Please Note: Anti-FGF1 (aFGF) Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | 031116C06
Size Price Quantity
100µg £178
200µg £259
1mg £682

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Lead Time: Currently 4-6 Days
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