+44 (0)1223 298875

Anti-Histone Deacetylase 1 Antibody

Mouse monoclonal antibody to Histone Deacetylase 1 from ABclonal (A0421).
Name: Anti-Histone Deacetylase 1 Antibody
Description: Mouse monoclonal antibody to Histone Deacetylase 1.
Applications: WB
Dilutions: WB: 1:200 - 1:2000.
Reactivity: Human
Immunogen: A synthetic peptide of human HDAC1.
Protein Length: 482
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
Tissue Specificity: Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 1 subfamily.
Post-Translational Modification: Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
Cellular Location: Nucleus.
UniProt: Q13547
Gene ID: 3065
Synonyms: DKFZp686H12203 Antibody
GON 10 Antibody
HD1 Antibody
HDAC 1 Antibody
HDAC1 Antibody
HDAC1_HUMAN Antibody
Reduced potassium dependency yeast homolog like 1 Antibody
RPD3 Antibody
RPD3L1 Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of HepG2 cell line, using HDAC1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to HDAC1.
Application: WB, IHC, IF
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Description: Rabbit polyclonal antibody to HDAC1
Application: WB, IHC, IF, IP, CHIP
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide of human HDAC1.

£234

Description: Goat polyclonal antibody to HDAC1.
Application: ELISA, WB, ChIP
Host: Goat
Isotype: IgG
Reactivity: Human, Mouse

£205

Total Citations (1)
Description: Rabbit polyclonal antibody to HDAC1 (E468)
Application: WB, IHC, IF
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 435-486 of Human HDAC1.

£165 – £283

Please Note: Anti-Histone Deacetylase 1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0421
Size Price Quantity
100µl £243
200µl £372

or
Request a quotation
Contact Us Directly
  • call icon + 44 (0)1223 298 875
  • + 44 (0)1223 281 447
  • email icon info@antibodies.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe