Ricombinante Anti-beta 2 Microglobulin Anticorpo [rB2M/7279] (A314503)

$765

Anticorpo monoclonale [rB2M/7279] di topo contro beta 2 Microglobulin per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-beta 2 Microglobulin Antibody [rB2M/7279]
Descrizione
Recombinant mouse monoclonal [rB2M/7279] antibody to beta 2 Microglobulin.
Specificità
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
Applicazioni
IHC-P
Controllo positivo
Raji, HL-60 or HeLa cells. Human carcinomas of stomach, cervix, endometrial, kidney or colon.
Diluizioni consigliate
IHC: 1-2 µg/ml
Reattività
Human, Non-Human Primates
Immunogeno
Recombinant full-length human B2M protein.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
rB2M/7279
Isotipo
IgG1
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A chromatography.
Concentrazione
200 µg/ml
Peso molecolare
12 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sinonimi
B2M, B2MG_HUMAN, Beta 2 microglobin, Beta 2 microglobulin precursor , Beta chain of mhc class 1 proteins , Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, CDABP0092, Hdcma22p, IMD43
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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