Anti-DC-SIGN Anticorpo [C209/6774] (A277641)

Anti-DC-SIGN Antibody [C209/6774]

Mouse monoclonal [C209/6774] antibody to DC-SIGN.

DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.

Flow Cytometry

Flow Cytometry: 0.5-1 µg/million cells

Human

Recombinant fragment corresponding to human CD209. The exact sequence is proprietary.

Mouse

Monoclonal

C209/6774

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

45 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-DC-SIGN Antibody [C209/6774] - BSA and Azide free (A278229).

C type lectin domain family 4 member L, C-type lectin domain family 4 member L, CD 209, CD209, CD209 antigen, CD209 antigen-like protein A, CD209 molecule, Cd209a, CD209_HUMAN, CDSIGN, CIRE, CLEC4L, DC SIGN, DC SIGN1, DC-SIGN1, DCSIGN, Dendritic cell specific ICAM 3 grabbing nonintegrin 1, Dendritic cell specific ICAM3 grabbing nonintegrin 1, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin, Dengue fever, protection against, included, Dentritic Cell Specific ICAM3 Grabbing Nonintegrin, HIV GP120 Binding Protein, MGC129965, MGC130443, SIGN-R1, SIGNR5