Anti-Desmoglein 1 Anticorpo [18D4] (A248366)

Anti-Desmoglein 1 Antibody [18D4]

Mouse monoclonal [18D4] antibody to Desmoglein 1.

This antibody recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Flow Cytometry, IF, WB

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human

Human Desmoglein-1 intracellular domain.

Mouse

Monoclonal

18D4

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

150 kDa (precursor) / 160 kDa (mature)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Desmoglein 1 Antibody [18D4] - BSA and Azide free (A251548).

Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DGI, DSG, DSG1, DSG1_HUMAN, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1