Ricombinante Anti-E Cadherin Anticorpo [rCDH1/7352] (A316284)

Anti-E Cadherin Antibody [rCDH1/7352] - BSA and Azide free

Recombinant mouse monoclonal [rCDH1/7352] antibody to E Cadherin.

Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.

IHC-P

Human prostate or colon carcinomas.

IHC: 1-2 µg/ml

Human

Recombinant full-length human E-Cadherin protein.

Mouse

Monoclonal

rCDH1/7352

kappa

Unconjugated

Protein A/G chromatography.

1 mg/ml

120-80 kDa (Mature) / 135 kDa (Precursor)

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Arc 1, CADH1_HUMAN, Cadherin 1, cadherin 1 type 1 E-cadherin, Cadherin1, CAM 120/80, CD 234, CD 324, CD324, CD324 antigen, CDH1, CDHE, E-Cad/CTF3, E-cadherin, ECAD , Epithelial cadherin, epithelial calcium dependant adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin