Anti-Fas Ligand Anticorpo [FASLG/4453] (A277667)

Anticorpo monoclonale [FASLG/4453] di topo contro Fas Ligand per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-Fas Ligand Antibody [FASLG/4453]
Descrizione
Mouse monoclonal [FASLG/4453] antibody to Fas Ligand.
Specificità
Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.
Applicazioni
IHC-P
Diluizioni consigliate
IHC-P: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment, around amino acids 107-222, of human Fas Ligand. The exact sequence is proprietary.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
FASLG/4453
Isotipo
IgG1
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
200 µg/ml
Peso molecolare
26 kDa (soluble FAS-L) / 40 kDa (FAS-L membrane)
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Fas Ligand Antibody [FASLG/4453] - BSA and Azide free (A278255).
Sinonimi
ALPS1B, Apoptosis (APO 1) antigen ligand 1, Apoptosis antigen ligand, Apoptosis antigen ligand 1, APT1LG1, APTL, CD178, CD178 antigen, CD95 L, CD95 ligand, CD95-L, CD95L, CD95L protein, Fas antigen ligand, Fas L, Fas ligand (TNF superfamily member 6), FASL, Fasl Fas ligand (TNF superfamily member 6), FASLG, Generalized lymphoproliferative disease, Gld, soluble form, TNF superfamily member 6, TNFL6_HUMAN, TNFSF6, Tumor necrosis factor (ligand) superfamily member 6, Tumor necrosis factor ligand superfamily member 6
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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