Anti-Fibrinogen Anticorpo [AB05-1F11] (A279622)

$340

Anticorpo monoclonale [AB05-1F11] di topo contro Fibrinogen per ELISA.

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-Fibrinogen Antibody [AB05-1F11]
Descrizione
Mouse monoclonal [AB05-1F11] antibody to Fibrinogen.
Specificità
This antibody recognises fibrinogen, a 340 kDa glycoprotein secreted by the liver which circulates in plasma as a soluble homodimer. The identical monomer subunits are linked by 17 disulfide bond and each subunit is composed of 3 polypeptide chains referred to as alpha, beta and gamma. In response to bleeding, the coagulation cascade is activated which results in the conversion of fibrinogen to fibrin. The resulting fibrin spontaneously forms polymers creating an insoluble gel which combines with platelets to form a spongy mass. This mass is the blood clot which subsequently hardens to prevent further bleeding from the blood vessel. The impairment of this conversion from fibrinogen to fibrin is associated with a range of pathologies including coagulopathies, ischemic stroke and obstetrical complications. It is also implicated in various neurological diseases such as Alzheimer’s, multiple sclerosis and traumatic central nervous system injury. The purified Mouse anti Human fibrinogen antibody, clone AB05-1F11 (MCA6190GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human fibrinogen antibody, clone AB10-3C12 (MCA6191B) as the detection antibody.
Applicazioni
ELISA
Diluizioni consigliate
ELISA: 1 µg/ml
Reattività
Human
Immunogeno
Fibrinogen purified from human serum.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
AB05-1F11
Isotipo
IgG1
Coniugare

Unconjugated

Purificazione
Protein G affinity chromatography of tissue culture supernatant.
Concentrazione
1 mg/ml
Forma del prodotto
Liquid
Formulazione
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Conservazione
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Note generali
Mouse anti Human fibrinogen antibody, clone AB05-1F11 recognizes fibrinogen, a 340 kDa glycoprotein secreted by the liver which circulates in plasma as a soluble homodimer. The identical monomer subunits are linked by 17 disulfide bond and each subunit is composed of 3 polypeptide chains referred to as alpha, beta and gamma (Tiscia & Margaglione 2018). In response to bleeding, the coagulation cascade is activated which results in the conversion of fibrinogen to fibrin. The resulting fibrin spontaneously forms polymers creating an insoluble gel which combines with platelets to form a spongy mass. This mass is the blood clot which subsequently hardens to prevent further bleeding from the blood vessel (Tiscia & Margaglione 2018). The impairment of this conversion from fibrinogen to fibrin is associated with a range of pathologies including coagulopathies, ischemic stroke and obstetrical complications. It is also implicated in various neurological diseases such as Alzheimer’s, multiple sclerosis and traumatic central nervous system injury (Petersen et al. 2018).The purified Mouse anti Human fibrinogen antibody, clone AB05-1F11 (MCA6190GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human fibrinogen antibody, clone AB10-3C12 (MCA6191B) as the detection antibody.
Sinonimi
FGA, Fib2, FIBA_HUMAN, Fibrinogen A alpha polypeptide, Fibrinogen alpha chain, Fibrinogen B alpha polypeptide, Fibrinogen beta chain, Fibrinogen G alpha polypeptide, Fibrinogen gamma chain, fibrinogen, B beta polypeptide, fibrinogen, G gamma polypeptide, fibrinogen, gamma polypeptide, Fibrinogen--alpha -polypeptide chain, Fibrinogen--beta -polypeptide chain, Fibrinogen--gamma-polypeptide chain
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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