Anti-Umano IgG4 Heavy Chain Anticorpo [IGHG4/1345] (A248950)

Anti-Human IgG4 Heavy Chain Antibody [IGHG4/1345]

Mouse monoclonal [IGHG4/1345] antibody to Human IgG4 Heavy Chain.

The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment of human IGHG4.

Mouse

Monoclonal

IGHG4/1345

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

150 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Human IgG4 Heavy Chain Antibody [IGHG4/1345] - BSA and Azide free (A252130).