Anti-IL-3 Anticorpo [IL3/4004] (A277669)

Name: Anti-IL-3 Antibody [IL3/4004]
Brand: Antibodies.com
SKU: A277669
Price: 525.0 USD
Availability: InStock

Clicca sull'immagine per la visualizzazione estesa

$525

Anticorpo monoclonale [IL3/4004] di topo contro IL-3 per IHC-P.

Garanzia al 100%

Garanzia di corrispondenza del prezzo

Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Consegna

Spese di spedizione

$40

Tempi di consegna

4-6 Giorni lavorativi

Contattaci

Telefono

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanzie

Garanzia di qualità al 100%

Garanzia di corrispondenza del prezzo

Tag dei prodotti:

Anticorpo Monospecifico

Descrizione Prodotto

Nome

Anti-IL-3 Antibody [IL3/4004]

Descrizione

Mouse monoclonal [IL3/4004] antibody to IL-3.

Specificità

Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific Î± subunit and a signal transducing Î² subunit common to the IL-3/IL-5/GM-CSF receptors. The carboxy terminus of the Î² subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.

Applicazioni

IHC-P

Diluizioni consigliate

IHC-P: 1-2 µg/ml

Reattività

Human

Immunogeno

Recombinant fragment corresponding to human IL-3 protein. The exact sequence is proprietary.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

IL3/4004

Isotipo

IgG1

Catene leggere

kappa

Coniugare

Unconjugated

Purificazione

Protein A/G chromatography.

Concentrazione

200 µg/ml

Peso molecolare

17 kDa

Forma del prodotto

Liquid

Formulazione

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conservazione

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Note generali

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-IL-3 Antibody [IL3/4004] - BSA and Azide free (A278257).

Sinonimi

Burst promoting activity, Colony stimulating factor multiple, Eosinophil colony stimulating factor, Hematopoietic growth factor, IL 3, IL3, IL3_HUMAN, Interleukin 3, Interleukin 3 (colony stimulating factor, multiple), Interleukin-3, Mast cell growth factor, MCGF, MGC79398, MGC79399, Multi CSF, Multilineage colony stimulating factor , Multipotential colony stimulating factor , Multipotential colony-stimulating factor, OTTHUMP00000065963, P cell stimulating factor , P-cell-stimulating factor, Thy1 inducing factor

Controlli isotipo

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Immagini (4)

Clicca sull'immagine per la visualizzazione estesa

Figure 1: Immunohistochemistry - Anti-IL-3 Antibody [IL3/4004] (A277669)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human adrenal gland tissue using Anti-IL-3 Antibody [IL3/4004].

Clicca sull'immagine per la visualizzazione estesa

Figure 2: Immunohistochemistry - Anti-IL-3 Antibody [IL3/4004] (A277669)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue using Anti-IL-3 Antibody [IL3/4004].

Clicca sull'immagine per la visualizzazione estesa

Figure 3: SDS-PAGE - Anti-IL-3 Antibody [IL3/4004] (A277669)

SDS-PAGE analysis of Anti-IL-3 Antibody [IL3/4004] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

Clicca sull'immagine per la visualizzazione estesa

Figure 4: Anti-IL-3 Antibody [IL3/4004] (A277669)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-IL-3 Antibody [IL3/4004]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.