Anti-IRF3 Anticorpo [PCRP-IRF3-3B2] (A278458)

Anticorpo monoclonale [PCRP-IRF3-3B2] di topo contro IRF3 per WB e IF.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-IRF3 Antibody [PCRP-IRF3-3B2] - BSA and Azide free
Descrizione
Mouse monoclonal [PCRP-IRF3-3B2] antibody to IRF3.
Specificità
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-αand β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-αand interferon-βgenes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γp48 and IFN consensus sequence-binding protein (ICSBP).
Applicazioni
WB, IF
Diluizioni consigliate
WB: 2-4 µg/ml, IF: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant full-length human IRF3 protein.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
PCRP-IRF3-3B2
Isotipo
IgG1
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
50 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-IRF3 Antibody [PCRP-IRF3-3B2] (A277870).
Sinonimi
IIAE7, Interferon regulatory factor 3, IRF 3, IRF-3, IRF3_HUMAN, MGC94729
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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