Anti-MAPK14 Anticorpo [CPTC-MAPK14-1] (A248270)

Anti-MAPK14 Antibody [CPTC-MAPK14-1]

Mouse monoclonal [CPTC-MAPK14-1] antibody to MAPK14.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. It has been implicated in various cancer pathologies and depending on the context, can facilitate or interfere with tumor development, and therefore has immense potential therapeutic interest.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human MAPK14 protein.

Mouse

Monoclonal

CPTC-MAPK14-1

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

41.6 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MAPK14 Antibody [CPTC-MAPK14-1] - BSA and Azide free (A251452).

CSAID binding protein, CSAID Binding Protein 1, CSAID-binding protein, Csaids binding protein, CSBP, CSBP 1, CSBP 2, CSBP1, CSBP2, CSPB1, Cytokine suppressive anti-inflammatory drug-binding protein, EXIP, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAPK 14, MAX interacting protein 2, MAX-interacting protein 2, Mitogen Activated Protein Kinase 14, Mitogen activated protein kinase p38 alpha, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, MK14_HUMAN, Mxi 2, MXI2, p38, p38 ALPHA, p38 MAP kinase, p38 MAPK, p38 mitogen activated protein kinase, p38ALPHA, p38alpha Exip, PRKM14, PRKM15, RK, SAPK2A