Anti-MSH2 Anticorpo [MSH2/3165] (A315331)

Anti-MSH2 Antibody [MSH2/3165]

Mouse monoclonal [MSH2/3165] antibody to MSH2.

Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.

WB, IHC-P

A549 or HepG2 cells. Human colon, thyroid, testis or lymph node.

WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 300-500) of human MSH2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

MSH2/3165

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

100 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

BAT26, COCA 1, COCA1, DNA mismatch repair protein Msh2, FCC 1, FCC1, hMSH2, HNPCC, HNPCC 1, HNPCC1, LCFS2, MSH 2, MSH2_HUMAN, MutS homolog 2, MutS homolog 2 colon cancer nonpolyposis type 1, MutS protein homolog 2