Anti-pan Cadherin Anticorpo [Pan-CAD/8020] (A315452)

Anti-pan Cadherin Antibody [Pan-CAD/8020]

Mouse monoclonal [Pan-CAD/8020] antibody to pan Cadherin.

Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin 6), R-cadherin, B-cadherin, E/P cadherin and cadherin-5.

IHC-P

Human heart, colon, prostate or brain.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human C-terminal of Pan-Cadherin. The exact sequence is proprietary.

Mouse

Monoclonal

Pan-CAD/8020

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

7B4 antigen, Cadherin, Cadherin-1, Cadherin-2, Cadherin-3, Cadherin-4, Cadherin-5, CAM 120/80, CD144, CD324, CD325, CDH3, Cdh4, CDH5, CDHE, CDHN, CDHP, E-cadherin, Epithelial cadherin, N-cadherin, NCAD, Neural cadherin, P-cadherin, Placental cadherin, UVO, Uvomorulin, Vascular endothelial cadherin