Anti-PDGFB Anticorpo [PDGFB/3071] (A278326)

Anticorpo monoclonale [PDGFB/3071] di topo contro PDGFB per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-PDGFB Antibody [PDGFB/3071] - BSA and Azide free
Descrizione
Mouse monoclonal [PDGFB/3071] antibody to PDGFB.
Specificità
PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains, A and B, and occurs as three isoforms; PDGF AA, AB and BB. The three isoforms bind, with different affinities, to two receptor types, αand β, which are structurally related and endowed with protein-tyrosine kinase domains. Ligand binding induces activation of the receptor kinases by formation of receptor dimers; the A subunit of PDGF binds only to α receptors with high affinity, whereas the B subunit can bind to both α and β receptors. Evidence suggests that PDGF may function as a neurotrophic factor. Receptors for PDGF-A are expressed in oligodendrocyte progenitor cells whereas receptors for PDGF-B are expressed on neurons. These facts suggest that the different isoforms of PDGF may regulate growth and differentiation of different cell types in the developing central nervous system through paracrine and autocrine routes.
Applicazioni
IHC-P
Diluizioni consigliate
IHC-P: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment, around amino acids 27-158, of human PDGFB protein. The exact sequence is proprietary.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
PDGFB/3071
Isotipo
IgG2c
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
14 kDa (monomeric B chain) / 31-35 kDa (dimer)
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-PDGFB Antibody [PDGFB/3071] (A277738).
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.
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