Apolipoprotein H è un gene codificato dal simbolo APOH. Altri nomi includono: Beta-2-glycoprotein 1; APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apo-H; Beta-2-glycoprotein I; B2GPI; APOH; B2G1. Apolipoprotein H ha una massa di 38.3kDa e una lunghezza di amminoacidi di 345.
Offriamo 5 Apolipoprotein H ELISA kit per il rilevamento qualitativo o quantitativo di Apolipoprotein H da campioni di Umano, Topo, Ratto e Bovino.
Informazioni su geni e proteine
Riepilogo UniProt
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Sommario di Entrez
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.
Specificità del tessuto
Expressed by the liver and secreted in plasma.
Modifica post-translazionale
N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.
Posizione cellulare
Secreted.
