Aquaporin 4 è un gene codificato dal simbolo AQP4. Altri nomi includono: Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4; AQP4. Aquaporin 4 ha una massa di 34.83kDa e una lunghezza di amminoacidi di 323.
Offriamo 8 Aquaporin 4 ELISA kit per il rilevamento qualitativo o quantitativo di Aquaporin 4 da campioni di Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).
Sommario di Entrez
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Specificità del tessuto
Detected in skeletal muscle (PubMed:29055082). Detected in stomach, along the glandular base region of the fundic gland (at protein level) (PubMed:8601457). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary (PubMed:7559426, PubMed:8601457).
Somiglianze di sequenza
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Modifica post-translazionale
Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40% (By similarity).
Posizione cellulare
Cell membrane. Basolateral cell membrane. Endosome membrane. Cell membrane > Sarcolemma. Cell projection.
Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries.
