Cathepsin L è un gene codificato dal simbolo CTSL. Altri nomi includono: Cathepsin L1; Major excreted protein; MEP; CTSL; CTSL1. Cathepsin L ha una massa di 37.56kDa e una lunghezza di amminoacidi di 333.
Offriamo 5 Cathepsin L ELISA kit per il rilevamento qualitativo o quantitativo di Cathepsin L da campioni di Umano, Topo, Ratto, Bovino e Maiale.
Informazioni su geni e proteine
Riepilogo UniProt
Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity).
Sommario di Entrez
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
Somiglianze di sequenza
Belongs to the peptidase C1 family.
Posizione cellulare
Lysosome. Apical cell membrane.
Localizes to the apical membrane of thyroid epithelial cells.
