eIF4EBP1 è un gene codificato dal simbolo EIF4EBP1. Altri nomi includono: Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I. eIF4EBP1 ha una massa di 12.58kDa e una lunghezza di amminoacidi di 118.
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Informazioni su geni e proteine
Riepilogo UniProt
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Sommario di Entrez
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Somiglianze di sequenza
Belongs to the eIF4E-binding protein family.
Modifica post-translazionale
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
