eNOS è un gene codificato dal simbolo NOS3. Altri nomi includono: Nitric oxide synthase, endothelial; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; NOS type III; NOSIII; NOS3. eNOS ha una massa di 133.28kDa e una lunghezza di amminoacidi di 1203.
Offriamo 13 eNOS ELISA kit per il rilevamento qualitativo o quantitativo di eNOS da campioni di Umano, Topo, Ratto, Bovino, Maiale, Coniglio, Pecora e Porcellino d'India.
Informazioni su geni e proteine
Riepilogo UniProt
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Sommario di Entrez
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Specificità del tessuto
Platelets, placenta, liver and kidney.
Somiglianze di sequenza
Belongs to the NOS family.
Modifica post-translazionale
Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity (By similarity). Phosphorylation of Ser-114 by CDK5 reduces activity.
Posizione cellulare
Cell membrane. Membrane > Caveola. Cytoplasm > Cytoskeleton. Golgi apparatus.
Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
