Lactoferrin è un gene codificato dal simbolo LTF. Comunemente indicato anche come: Lactotransferrin; Growth-inhibiting protein 12; TalaLTF; GIG12; LF. Lactoferrin ha una massa di 78.18kDa e una lunghezza di amminoacidi di 710.
Offriamo 10 Lactoferrin ELISA kit per il rilevamento qualitativo o quantitativo di Lactoferrin da campioni di Umano, Topo, Ratto, Bovino, Maiale e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
Sommario di Entrez
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level). Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.
Somiglianze di sequenza
Belongs to the transferrin family.
Modifica post-translazionale
Phosphorylation at Ser-10 activates the transcriptional activity (PubMed:20404350). Phosphorylation at Ser-10 also promotes proteasomal degradation (PubMed:20404350). Alternatively can undergo O-GlcNAcylation at Ser-10 (PubMed:20404350).
Posizione cellulare
Secreted. Cytoplasmic granule.
Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.
