Macrophage Inflammatory Protein 3 beta è un gene codificato dal simbolo CCL19. Comunemente indicato anche come: C-C motif chemokine 19; Beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; MIP-3-beta; Small-inducible cytokine A19; CCL19; ELC; MIP3B; SCYA19. Macrophage Inflammatory Protein 3 beta ha una massa di 10.99kDa e una lunghezza di amminoacidi di 98.
Offriamo 5 Macrophage Inflammatory Protein 3 beta ELISA kit per il rilevamento qualitativo o quantitativo di Macrophage Inflammatory Protein 3 beta da campioni di Umano, Topo, Ratto, Maiale e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Sommario di Entrez
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
Specificità del tessuto
Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
Somiglianze di sequenza
Belongs to the intercrine beta (chemokine CC) family.
Posizione cellulare
Secreted.
