Thrombopoietin è un gene codificato dal simbolo THPO. È noto anche come: C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand; THPO. Thrombopoietin ha una massa di 37.82kDa, una lunghezza di amminoacidi di 353, ed è implicato in Thrombocythemia 1.
Offriamo 12 Thrombopoietin ELISA kit per il rilevamento qualitativo o quantitativo di Thrombopoietin da campioni di Umano, Topo, Ratto, Bovino e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Sommario di Entrez
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.
Coinvolgimento nella malattia
Thrombocythemia 1: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
Somiglianze di sequenza
Belongs to the EPO/TPO family.
Posizione cellulare
Secreted.
