ADCY8 è un gene codificato dal simbolo ADCY8. Altri nomi includono: Adenylate cyclase type 8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase. ADCY8 ha una massa di 140.12kDa e una lunghezza di amminoacidi di 1251.
Offriamo 6 anticorpi contro ADCY8, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
Sommario di Entrez
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
Specificità del tessuto
Detected in brain cortex (PubMed:1715695). Expressed in islet (PubMed:25403481).
Somiglianze di sequenza
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Modifica post-translazionale
Phosphorylated by PKA; mediates inhibition of adenylate cyclase activity at membrane raft; does not influence either CALM1 or PPP2CA interaction with ADCY8.
Posizione cellulare
Cell membrane. Basolateral cell membrane. Apical cell membrane. Cell junction > Synapse. Cell projection > Dendrite. Cell projection > Axon. Cell junction > Synapse > Presynaptic cell membrane. Cell junction > Synapse > Postsynaptic density. Membrane raft. Membrane > Coated pit. Cytoplasmic vesicle > Clathrin-coated vesicle membrane. Membrane > Caveola.
Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity).
