ALDH1A1 è un gene codificato dal simbolo ALDH1A1. Altri nomi includono: Retinal dehydrogenase 1; RALDH 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; ALDC; ALDH1; PUMB1. ALDH1A1 ha una massa di 54.86kDa e una lunghezza di amminoacidi di 501.
Offriamo 22 anticorpi contro ALDH1A1, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233).
Sommario di Entrez
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.
Somiglianze di sequenza
Belongs to the aldehyde dehydrogenase family.
Modifica post-translazionale
The N-terminus is blocked most probably by acetylation.
Posizione cellulare
Cytoplasm > Cytosol.
