Apc1 è un gene codificato dal simbolo ANAPC1. Altri nomi includono: Anaphase-promoting complex subunit 1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein; ANTSG24. Apc1 ha una massa di 216.5kDa e una lunghezza di amminoacidi di 1944.
Offriamo 10 anticorpi contro Apc1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Sommario di Entrez
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation.
Somiglianze di sequenza
Belongs to the APC1 family.
Modifica post-translazionale
Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.
