Apolipoprotein L 1 è un gene codificato dal simbolo APOL1. Altri nomi includono: Apolipoprotein L1; Apolipoprotein L; Apo-L; Apolipoprotein L-I; ApoL-I; APOL1; APOL. Apolipoprotein L 1 ha una massa di 43.97kDa, una lunghezza di amminoacidi di 398, ed è implicato in Focal segmental glomerulosclerosis 4.
Offriamo 7 anticorpi contro Apolipoprotein L 1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
Sommario di Entrez
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.
Coinvolgimento nella malattia
Focal segmental glomerulosclerosis 4: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Somiglianze di sequenza
Belongs to the apolipoprotein L family.
Modifica post-translazionale
Phosphorylated by FAM20C in the extracellular medium.
Posizione cellulare
Secreted.
