ASF1A è un gene codificato dal simbolo ASF1A. Altri nomi includono: Histone chaperone Anti-silencing function protein 1 homolog A; hAsf1; CCG1-interacting factor A; CIA. ASF1A ha una massa di 22.97kDa e una lunghezza di amminoacidi di 204.
Offriamo 11 anticorpi contro ASF1A, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e Dot con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Sommario di Entrez
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.
Specificità del tessuto
Ubiquitously expressed.
Somiglianze di sequenza
Belongs to the ASF1 family.
Modifica post-translazionale
Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.
Posizione cellulare
Nucleus.
