Bak è un gene codificato dal simbolo BAK1. Altri nomi includono: Bcl-2 homologous antagonist/killer; Apoptosis regulator Bcl-2-like protein 7; Bcl2-L-71; BCL2L7; CDN1. Bak ha una massa di 23.41kDa e una lunghezza di amminoacidi di 211.
Offriamo 12 anticorpi contro Bak, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Sommario di Entrez
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Specificità del tessuto
Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Somiglianze di sequenza
Belongs to the Bcl-2 family.
Posizione cellulare
Mitochondrion outer membrane.
