Cathepsin K è un gene codificato dal simbolo CTSK. Altri nomi includono: Cathepsin O; Cathepsin O2; Cathepsin X; CTSK; CTSO; CTSO2. Cathepsin K ha una massa di 36.97kDa, una lunghezza di amminoacidi di 329, ed è implicato in Pycnodysostosis.
Offriamo 10 anticorpi contro Cathepsin K, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
Sommario di Entrez
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.
Specificità del tessuto
Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042).
Coinvolgimento nella malattia
Pycnodysostosis: A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.
Somiglianze di sequenza
Belongs to the peptidase C1 family.
Posizione cellulare
Lysosome. Secreted. Apical cell membrane.
Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
