CD300 antigen è un gene codificato dal simbolo CD300A. Altri nomi includono: CMRF35-like molecule 8; CLM-8-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD300A; CMRF35H; IGSF12. CD300 antigen ha una massa di 33.2kDa e una lunghezza di amminoacidi di 299.
Offriamo 8 anticorpi contro CD300 antigen, allevati nel Coniglio e Topo, che sono adatti per WB e Citometria a Flusso con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).
Sommario di Entrez
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
Somiglianze di sequenza
Belongs to the CD300 family.
Modifica post-translazionale
Phosphorylated on tyrosine.
Posizione cellulare
Cell membrane.
