CD53 è un gene codificato dal simbolo CD53. Altri nomi includono: Leukocyte surface antigen Cell surface glycoprotein Tetraspanin-25; Tspan-25; MOX44; TSPAN25. CD53 ha una massa di 24.34kDa e una lunghezza di amminoacidi di 219.
Offriamo 12 anticorpi contro CD53, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
Sommario di Entrez
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.
Somiglianze di sequenza
Belongs to the tetraspanin (TM4SF) family.
Posizione cellulare
Cell membrane. Cell junction. Membrane.
Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.
