CD86 è un gene codificato dal simbolo CD86. Altri nomi includono: T-lymphocyte activation antigen Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD28LG2. CD86 ha una massa di 37.68kDa e una lunghezza di amminoacidi di 329.
Offriamo 65 anticorpi contro CD86, allevati nel Coniglio, Topo e Ratto, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Bovino e Pecora.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Sommario di Entrez
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
Specificità del tessuto
Expressed by activated B-lymphocytes and monocytes.
Modifica post-translazionale
Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Posizione cellulare
Cell membrane.
